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Ghrelin is an appetite-stimulating peptide hormone secreted by P/D1 cells in the human stomach, which circulates in the blood during fasting. The 28 amino acid Ghrelin is the endogenous ligand of growth hormone secretory hormone receptor 1a (GHSR1a), and the N-octanoyl serine 3 of enzyme growth hormone is the endogenous ligand of growth hormone secretory hormone receptor 1a (GHSR1a). GHSR1a receptor is related to Ghrelin and is widely expressed in different tissues.