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Hydrocodone works in the cerebrum and responds to the pain. Hydrocodone can be taken with food or with an empty stomach. You should use hydrocodone, as directed by a health practitioner. The dosage of this pain medicine is based on your pain condition. It works best if it is used as the first pain signal occurs. It suppresses the intensity of different type of pain. Hydrocodone is useful and usually prescribe to the patients who are suffering from severe or intense pains after surgeries, fractures or multiple injuries. So if you are suffering from a couple of pains than you need to use hydrocodone. When you use this medicine, it’s very important to keep in mind that doesn’t take overdose of hydrocodone. It should be used for a short time period.