Company description
Apoptosis signal-regulating kinase 1(ASK1) is a member of MAP kinase kinase kinase family and as such a part of mitogen-activated protein kinase pathway. It activates c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases in a Raf-independent fashion in response to an array of stresses such as oxidative stress, endoplasmic reticulum stress and calcium influx. It has been found to be involved in cancer, diabetes, cardiovascular and neurodegenerative diseases.
